Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix assemblies in the adult rat cortex
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چکیده
منابع مشابه
Entorhinal cortex lesion in adult rats induces the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes.
The chondroitin sulfate proteoglycan neurocan is a major component of brain extracellular matrix during development. Neurocan is primarily synthesized by neurons and has the ability to interact with cell adhesion molecules involved in the regulation of cell migration and axonal growth. Within the first weeks postnatally, neurocan expression is strongly downregulated. To test whether neurocan is...
متن کاملA large chondroitin sulfate proteoglycan has the characteristics of a general extracellular matrix component of adult brain.
Extracellular matrix (ECM) is a secreted extracellular network. Few components of adult brain ECM are known. We have identified a new, large chondroitin sulfate proteoglycan (T1 antigen) that acts like a general ECM protein of brain. First, it is present throughout the brain; second, it has the properties of an extracellular protein; and third, it is extracted only under denaturing conditions. ...
متن کاملOccurrence of three distinct molecular species of chondroitin sulfate proteoglycan in the developing rat brain.
More than 60% of brain chondroitin sulfate proteoglycans were extracted from 10-day-old rat brains by homogenization in ice-cold phosphate-buffered saline containing protease inhibitors. Although the soluble proteoglycan preparation was a mixture of chondroitin sulfate proteoglycans with a different hydrodynamic size as well as a different molecular density, each subfraction of the proteoglycan...
متن کاملInhibition of neurite growth by the NG2 chondroitin sulfate proteoglycan.
The chondroitin sulfate proteoglycans (CSPGs) have been implicated as both positive and negative modulators of axonal growth; however, the functional properties of only a few specific CSPGs have been investigated. Here we demonstrate that NG2, an integral membrane CSPG expressed on the surfaces of glial progenitor cells, inhibits neurite growth from neonatal rat cerebellar granule neurons when ...
متن کاملIdentification of a nervous tissue-specific chondroitin sulfate proteoglycan, neurocan, in developing rat retina.
PURPOSE To identify the expression of neurocan, a nervous tissue-specific chondroitin sulfate proteoglycan, in retina and to elucidate its changes during development. METHODS Expressional changes of neurocan mRNAs in developing rat retinas were investigated by a semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). The localization and characterization of neurocan core pr...
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ژورنال
عنوان ژورنال: Cellular Signalling
سال: 2020
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2020.109710